Biologique Recherche Crème PTO Métamorphique is the newest innovation in age-defying skincare—engineered to visibly lift, firm, and sculpt the face and neck. Developed through years of research and clinical testing, this advanced formula directly addresses one of the most common aging concerns: Ptosis, or sagging skin caused by muscle weakening.
Replacing the cult-favorite Crème ADN Métamorphique, this next-generation cream delivers targeted results with an improved formula and refined texture.
What Is Crème PTO Métamorphique?
Crème PTO Métamorphique is a high-performance anti-aging cream designed to treat skin laxity and loss of definition caused by Ptosis—a natural weakening of facial muscles over time. This firming face and neck cream is ideal for those noticing sagging around the jawline, cheeks, eyelids, or neck.

What Does “PTO” Mean?
“PTO” stands for Ptosis, a term used in dermatology to describe the drooping or sagging of skin due to muscle weakening. It’s a common age-related concern that affects facial contours, particularly around the eyes, mouth, and jawline. This cream was developed specifically to address this issue.
Crème PTO vs. Crème ADN Métamorphique
Crème PTO Métamorphique is the evolution of Crème ADN Métamorphique. While the formulas share a similar structure, the key difference lies in the replacement of the DNA-protective active ingredient with a more powerful tensor complex to enhance the lifting effect.
Key Enhancements:
- Stronger firming action
- Improved texture – slightly firmer, breaks down easily during application
- Beige tint – slightly more pigmented than the original
- Better absorption and performance – clinical studies show a -6% reduction in visible Ptosis after 28 days
What Does It Do?
With regular use, Crème PTO Métamorphique helps:
- Firm and tone sagging skin
- Reshape and define facial contours
- Reduce the appearance of Ptosis
- Lift the jawline, neck, and cheeks
It’s suitable for mature skin or those beginning to notice loss of elasticity and firmness.
Can It Be Used on the Neck?
Yes. Crème PTO Métamorphique is specifically formulated for use on the face, neck, and décolleté. It targets areas prone to sagging—like under the chin and along the jawline—with visible tightening and sculpting effects.
Best Serums to Pair with Crème PTO
To enhance its lifting and firming power, pair Crème PTO Métamorphique with these Biologique Recherche serums:
- Sérum Progeskin – Revitalizes and strengthens the skin’s structure
- Sérum Collagène Originel – Boosts collagen and smooths the skin
- Sérum VG Tensil – Provides immediate firming and toning benefits
Together, these formulas deliver a multi-layered approach to firming and redefining the skin.
When Is It Available?
Crème PTO Métamorphique is available starting May 20th. Look for it online and at select Biologique Recherche retail partners and skincare professionals.
Is Crème ADN Still Available?
Yes—but only in limited quantities. Crème ADN Métamorphique is being phased out and will no longer be produced. Remaining stock has an expiration date of August 2028, so if you’ve loved this formula in the past, now is the time to stock up before transitioning to the updated version.
Is the Crème PTO Métamorphique right for me?
Crème PTO Métamorphique marks a significant advancement in anti-aging skincare. With a firmer texture, more powerful active ingredients, and clinically proven results, it is an ideal upgrade for anyone seeking to lift and sculpt the face and neck.
Whether you’re dealing with early signs of sagging or looking to redefine your facial contours, this cream offers a next-level solution—crafted with the precision and efficacy Biologique Recherche is known for.